Fractyl Health Mourns the Passing of Esteemed Board Member Brian Dovey

LEXINGTON, Mass.–(BUSINESS WIRE)– It is with profound sadness that Fractyl Health announces the passing of Brian Dovey, a cherished member of our
Board of Directors and a partner at Domain Associates, following a short illness.

With a career spanning more than four decades in the life sciences sector, Brian was a stalwart in the industry, contributing immeasurably to its growth and
evolution. His extensive expertise, leadership, and insight were instrumental in guiding numerous companies, including Fractyl Health, towards innovative
solutions offering new options for patients.

“Brian’s passing is a deep loss for me, the Fractyl Health family and the broader life sciences venture capital community,” said Dr. Harith Rajagopalan, Cofounder and CEO of Fractyl Health. “He was not only a visionary leader but also a mentor and a friend. His legacy will continue to inspire and guide our efforts.”

Over the years, Brian’s leadership roles spanned various organizations, from venture capital firms to biopharmaceutical companies, leaving an indelible mark
wherever he went. His passion for fostering innovative medical solutions has led to breakthroughs that continue to benefit patients worldwide.

The entire Fractyl Health team extends its heartfelt condolences to Brian’s family, friends, and colleagues. We will forever remember and honor his commitment
to advancing healthcare, his pithy quips, and his unwavering support for our mission.

About Fractyl Health

Fractyl Health is focused on pioneering new approaches to the treatment of T2D. Despite advances in treatment over the last 50 years, T2D and obesity
continue to be rapidly growing drivers of morbidity and mortality in the 21st century. Fractyl Health’s goal is to transform T2D treatment from chronic blood
glucose management to disease-modifying therapies that target the organ-level root causes of the disease. Fractyl Health is a private organ-editing metabolic
therapeutics company based in Lexington, MA. For more information, visit www.fractyl.com or www.twitter.com/FractylHealth.

Contacts
Corporate Contact
Lisa Davidson, Chief Financial Officer
Lisa@fractyl.com, 781.902.8800

Media Contact
Beth Brett, Corporate Communications
Bbrett@fractyl.com, 720.656.6544