We target root causes of obesity and type 2 diabetes.
Obesity and type 2 diabetes are progressive metabolic diseases. The current standard of care focuses on managing disease symptoms like body weight and blood sugar with drug regimens that do not prevent these illnesses from getting worse. Unfortunately, these symptoms tend to get more severe despite medical treatment, causing many patients to require not only lifelong treatment but also an escalation of drug therapy—in an attempt to control their disease.
We believe that new approaches are needed to address obesity and type 2 diabetes to break the pattern of chronic medications and free patients from the burden of these diseases. Our goal is to prevent and reverse metabolic diseases by treating their root causes in the key metabolic control organs of the gut—the duodenum and the pancreas.
The gut plays a key role in metabolic health.
Duodenum
The duodenum is the first part of the small intestine. It plays a key role in sensing nutrients from food and communicating these signals to the brain and the body in order to regulate metabolic responses to food intake.
Modern diets, high in fat and sugar, can damage the duodenum and change its structure and function, which impacts appetite and blood sugar control and can lead to obesity and type 2 diabetes.
Pancreas
Specialized cells in the pancreas (beta cells) are designed to produce and secrete insulin into the bloodstream to control blood sugar levels. When a person lives with obesity, high insulin levels drive even more hunger and weight gain.
Over time, type 2 diabetes occurs in some people when chronic overuse of these beta cells causes them to begin to fail and lose their ability to produce enough insulin to keep blood sugar levels low.
We are innovators working to break the pattern in serious metabolic diseases.
We are pioneers in developing innovative approaches to prevent and reverse metabolic diseases through an advanced understanding of their root causes. Our team has the expertise and passion needed to lead the paradigm shift in how to restore metabolic health.
We have one goal: to develop life-changing therapies that can change the course of obesity and type 2 diabetes for patients and their families.