Fractyl Logo

A NEW APPROACH
TO TYPE 2 DIABETES
AND OBESITY

WE ARE FOCUSED ON TRANSFORMING THE TREATMENT OF METABOLIC DISEASES

Type 2 diabetes (T2D) is a progressive metabolic disease. This means the disease affects how the body turns food into energy and disrupts the ability of the body to set (regulate) the correct levels of sugar in the blood. Blood sugar that rises and is not controlled over a long period of time can lead to life-threatening problems, including heart disease, kidney disease, and nerve damage.

Traditionally, T2D treatments have focused on managing the symptoms of the disease, such as increased blood sugar. But treating the symptoms alone does not prevent the disease from getting steadily worse. Because T2D keeps progressing, many people require more medications to be added over time as they try to control their blood sugar, and, eventually, they may even require insulin therapy to treat rising blood sugar.

We believe that new approaches are needed to address T2D. Our goal is to treat the cause of diabetes, which we believe is in the gut (the duodenum), instead of trying to manage the symptoms. These will continue to get worse even with glucose lowering medications. We believe that the products we are developing, if approved, have the potential to keep the disease from progressing and can potentially minimize or eliminate the need for medications, which are so difficult to manage.

ALTERNATIVES TO INSULIN ARE DESPERATELY NEEDED

Insulin therapy is very effective at lowering blood sugar in clinical trials, but poses significant challenges for patients as a sustainable therapy. Only 30% of people achieve good glycemic control even after long-acting insulin is added to their regime of other medicines. Insulin has several problems that prevent it from being more effective for patients, such as significant side effects, high burden of insulin medication management, increasing need for insulin as T2D worsens, and escalating cost.
We believe there is a significant unment need for therapies that offer the potential to reduce daily disease management, particularly with insulin. We are seeking to create new therapies that aim to interrupt the progression of disease, are easy to administer, and can be easy to access.

Dr. Rajagopalan MD, PhD on why alternatives to insulin are desperately needed

Revitalize 1 Study logo

Enrolling Today


If you have type 2 diabetes, you could benefit from a clinical research study evaluating a non-drug procedure that may help improve blood sugar without increasing medicines or insulin. Revitalize 1 (NCT #04419779) is a pivotal clinical study of an investigational procedure called Revita® and is expected to enroll more than 500 people with T2D across 35 procedure centers in the United States and Europe.

Learn More about Revitalize 1

Revita is now available in Germany